Reticulocytes

Your journey to good health begins at IntroLab.

300,00 rsd

Obrtno Vreme

1 day

Uzorkovanje

Blood drawing

Kategorija

Hematology

IntroLab offers reliable and precise reticulocyte analyses that enable you to gain detailed insight into your blood’s regeneration. Our team of expert laboratory technicians uses advanced hematological analyzers to determine the number and percentage of reticulocytes accurately. These values allow us to assess the effectiveness of erythrocyte regeneration and provide relevant information about your health. If you would like to learn more about reticulocyte analysis and its importance, please feel free to contact us.

What are Reticulocytes?

Reticulocytes are young erythrocytes, or red blood cells, found in blood circulation. These young red blood cells have characteristic net-like structures (reticulum) that are visible under a microscope. Reticulocytes are a phase of erythropoiesis, the process of creating new red blood cells, and serve as precursors to mature erythrocytes.

When the body needs to increase red blood cell production, such as in cases of anemia or after blood loss, the bone marrow accelerates the production of reticulocytes to compensate for the shortage of red blood cells. The number of reticulocytes in the blood can be an indicator of the effectiveness of erythrocyte regeneration and the body’s recovery.

Reticulocytes usually remain in circulation for only a few days before maturing into fully developed erythrocytes. Therefore, their number in the blood reflects the balance between the creation of new erythrocytes and the breakdown of old ones.

When is Reticulocyte analysis recommended?

Reticulocyte analysis is recommended when blood cell regeneration needs to be assessed. It is often used for patients with anemia, bone marrow disorders, or after a blood transfusion. Reticulocytes are young erythrocytes in circulation, and their number can indicate the efficiency of the erythrocyte regeneration process.

Reticulocyte analysis: Key indicator for assessing blood health at Introlab laboratory

In our laboratory, reticulocyte analysis is conducted using high-quality hematological analyzers. These sophisticated devices automatically determine the number of reticulocytes, based on which various parameters important for assessing erythropoiesis and blood health are calculated.

In addition to the standard calculation of the relative number of reticulocytes in percentages, we also calculate the absolute number of reticulocytes, which represents the percentage of reticulocytes multiplied by the number of erythrocytes. This approach allows us to obtain a more precise insight into the regenerative potential of the body.

We also classify reticulocytes based on their intensity of fluorescence, allowing us to distinguish three subgroups of reticulocytes: LFR (low fluorescence reticulocytes), MFR (medium fluorescence reticulocytes), and HFR (high fluorescence reticulocytes). Additionally, we calculate the IFR (immature reticulocyte fraction) as the sum of MFR and HFR, providing further information on the body’s regenerative potential.

Furthermore, our hematological analyzers enable the measurement of hemoglobin content in reticulocytes (RET-He). This parameter provides insight into the current iron supply during erythropoiesis, which is useful for assessing the “quality” of erythrocytes before reticulocytes mature into mature erythrocytes.

We interpret the results of reticulocyte analysis in combination with other results from the complete blood count, erythrocytes, hemoglobin, and hematocrit. This comprehensive analysis enables us to differentiate between various types of anemias (hypo-, normo-, and hyper-regenerative forms) and to monitor the response to therapy in cases of deficient anemias.

The Reticulocyte Production Index (RPI) is another parameter we use to measure erythropoiesis, independent of the reticulocyte count. It is calculated by considering the percentage of reticulocytes, hematocrit, and a correction factor depending on the patient’s hematocrit. This measure allows us to assess the rate and efficiency of erythrocyte production.

In our laboratory, we are committed to high standards of quality and accuracy in performing reticulocyte analysis. Our expert team will carefully process your samples and provide you with detailed results with interpretations.

Decreased and increased reticulocyte values: What they reveal and possible causes

Reticulocytes are an important indicator of blood regeneration, and their values can indicate various health conditions. Decreased reticulocyte levels, along with reduced values of erythrocytes, hemoglobin, and hematocrit, often occur in anemias due to:

  • Iron deficiency
  • Pernicious anemia
  • Aplastic anemia
  • Radiation exposure
  • Bone marrow insufficiency due to infection or cancer
  • Kidney diseases
  • Alcoholism
  • Endocrine diseases

On the other hand, increased reticulocyte levels, with reduced values of erythrocytes, hemoglobin, and hematocrit, can be a result of:

  • Bleeding
  • Hemolytic anemia
  • Neonatal hemolytic disease

Additionally, elevated reticulocyte values can occur when there is hyperproduction of erythrocytes, which is characteristic of polycythemia vera or the presence of tumors that produce erythropoietin.

It is important to note that interpreting reticulocyte values is complex and requires considering results in the context of other complete blood count parameters. In our laboratory, the expert team will carefully analyze the results and provide you with precise interpretations so you can get a comprehensive picture of your health and blood regeneration.

Preparation for the analysis

No special preparation is needed for reticulocyte analysis. Patients can adhere to their usual routine before taking a blood sample. However, it is advisable not to perform the analysis immediately after eating.

Vrsta uzorka i vreme kada se uzima uzorak

Uzorak: Full venous blood (adults), full capillary blood taken from the finger (adults, children) or heel (newborns).

Obrtno vreme: 1 day

Priprema: No special preparation is needed, however, it is advisable not to take the sample immediately after a meal.

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