Immunoglobulin E (IgE)

As part of our private laboratory in Belgrade, IntroLab, we perform Immunoglobulin E (IgE) analysis. The Immunoglobulin E (IgE) analysis allows for the assessment of immune status and the detection of elevated or reduced IgE antibody levels in the blood, which may result from allergic reactions, parasitic infections, as well as certain systemic and hereditary diseases. This test is important for diagnosing and monitoring immune disorders and allows for the adjustment of therapy.

When is the Immunoglobulin E (IgE) analysis indicated?

Testing Immunoglobulin E (IgE) levels plays a significant role in assessing a person’s immune system. Determining elevated or reduced levels of this immunoglobulin is fundamental in diagnosing and monitoring various diseases and conditions. The IgE analysis is particularly used for screening allergic reactions and parasitic infections. Additionally, a reduction in IgE levels may be associated with hereditary or acquired immunodeficiencies, along with a decrease in other immunoglobulins. For this reason, additional immunological blood tests are often required alongside this one.

Interpreting the results

Reduced levels of Immunoglobulin E (IgE) may indicate certain conditions or disorders of the immune system, such as:

• Primary immunodeficiency: A reduction in IgE levels may be associated with certain primary immunodeficiency syndromes, such as selective IgE deficiency or hyper-IgM syndrome.
• Systemic lupus erythematosus: A reduction in IgE levels may be observed in some patients with systemic lupus erythematosus (SLE), an autoimmune disease that can affect the immune system.
• Cellular immunodeficiency syndromes: Certain cellular immunodeficiency syndromes may be associated with reduced IgE levels, such as Wiskott-Aldrich syndrome.

On the other hand, elevated IgE levels may indicate the following conditions or situations:

• Allergic reactions: Elevated IgE levels are often associated with allergic reactions to certain allergens, such as pollen, dust, food, or insect stings.
• Asthma: Asthmatic patients often show elevated IgE levels, and IgE levels can also be used to assess the severity of asthma and choose appropriate therapy.
• Parasitic infections: Elevated IgE levels may result from parasitic infections, such as tapeworm or roundworm infections.