Catecholamines (Adrenaline, Noradrenaline, Dopamine) in Plasma

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4100,00 rsd

Obrtno Vreme

8 days

Uzorkovanje

Blood Draw

Kategorija

Immunohemistry

At IntroLab, we provide plasma catecholamine testing to measure the levels of these essential neurotransmitters in the bloodstream.

What are plasma catecholamines?

Plasma catecholamines are a group of biogenic amines, including adrenaline, noradrenaline, and dopamine, present in the body’s circulation. These neurotransmitters play crucial roles in the central nervous system and other parts of the body.

Catecholamines are vital for regulating numerous physiological functions. They influence the tone of smooth muscles in blood vessels, intestines, and bronchi, affecting blood flow and organ function. They also regulate heart rate and contractility, which is essential for maintaining blood pressure and supplying the body with oxygen and nutrients. Additionally, catecholamines are involved in glucose metabolism, important for maintaining the body’s energy balance.

In circulation, catecholamines mainly originate from the adrenal glands, located above the kidneys. When the body is under stress, these glands release catecholamines into the bloodstream, where they travel to various parts of the body and impact different physiological processes.

Why is plasma catecholamine testing done?

Plasma catecholamine testing is used to detect tumors that secrete catecholamines, such as pheochromocytoma, neuroblastoma, and paraganglioma. Symptoms that may indicate the need for this test include high blood pressure accompanied by severe headaches, rapid heart rate, and sweating.

Who should get tested?

This test is usually recommended for individuals with symptoms or conditions that may suggest problems with catecholamines. This includes people with chronic or episodic hypertension, severe headaches, rapid heart rate, sweating, and those diagnosed with pheochromocytoma or neuroendocrine tumors.

Low values

Low concentrations of catecholamines in plasma or values within the reference range do not automatically rule out the presence of disease. For example, patients with pheochromocytoma or neuroblastoma may experience periods of high blood pressure, while in intervals between these episodes, plasma catecholamine levels may be normal or even low.

High values

Elevated concentrations of catecholamines in plasma can occur in conditions such as pheochromocytoma, neuroblastoma, and paraganglioma. However, interpreting these results requires a careful approach, as various factors can lead to temporary increases in plasma catecholamines. These factors include:

  • Stress
  • Upright body position
  • Physical activity
  • Low blood sugar (hypoglycemia)
  • Low blood volume (hypovolemia)
  • Exposure to cold
  • Oxygen deficiency (hypoxia)
  • Conditions such as hypothyroidism
  • Congenital heart defects

Elevated plasma catecholamine levels are not definitive proof of the presence or absence of disease. The interpretation of these test results should be done by a physician, considering other diagnostic tests and the overall clinical picture of the patient.

Specifics and subtypes of the test

There are various subtypes of plasma catecholamine testing, tailored to the specific needs of the patient. For instance, in the case of pheochromocytoma, the initial tests typically involve measuring metanephrines in blood or 24-hour urine. If these tests do not rule out the diagnosis, then catecholamines in 24-hour urine or blood are measured.

Vrsta uzorka i vreme kada se uzima uzorak

Uzorak: EDTA plasma (venous blood)

Obrtno vreme: 8 days

Priprema: Before having a blood sample taken for catecholamine analysis, patients are advised to rest and lie down for 15 to 30 minutes. It is also recommended to avoid eating, smoking, and consuming coffee, tea, or any other caffeinated beverages for at least 4 hours before the test.

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