C-peptide in urine

C-Peptide is a molecule of crucial importance for understanding and monitoring diabetes and other metabolic conditions. Our laboratory, IntroLab in Belgrade, provides this analysis, ensuring reliability and precision at every step.

What is C-peptide?

C-peptide is a specific protein fragment that is produced during the cleavage of proinsulin, the precursor of insulin, within the pancreas. This molecule plays a key role in assessing pancreatic function and insulin production in the body, which can be evaluated by measuring its concentration in urine.

On a molecular level, C-peptide is a polypeptide composed of 31 amino acids. It forms a single-chain structure and has an average molecular weight of 3.2 kDa. Although it may seem like a relatively small molecule, its role in the body is extremely important.

One of the most significant characteristics of C-peptide is its concentration in peripheral circulation. Compared to insulin, C-peptide is present in concentrations that are 5 to 10 times higher and more stable. This property makes C-peptide a key indicator in assessing pancreatic function and insulin production, which is essential for understanding and managing metabolic conditions like diabetes.

Why is C-peptide analysis in urine important?

Measuring C-peptide is important because it helps doctors distinguish between type 1 and type 2 diabetes, as well as assess the condition of individuals with insulin resistance. Additionally, the C-peptide test can be used to monitor the effectiveness of diabetes therapy and confirm the diagnosis of insulinoma, a rare pancreatic tumor that produces insulin.

When is it necessary to perform the C-peptide test in urine?

The analysis of C-peptide in urine is recommended for individuals who have symptoms of:

• Diabetes
• Insulin resistance
• Hypoglycemia

Also, if you have already been diagnosed with diabetes, this test can be useful for monitoring the effectiveness of therapy.

Decreased and increased levels

Conditions that may lead to decreased levels of C-peptide:

• Hypoinsulinism (often associated with type 1 diabetes)
• Prolonged fasting
• Artificially induced hypoglycemia
• Addison’s disease
• State after surgical removal of the pancreas (pancreatectomy)

Conditions that may lead to increased levels of C-peptide:

• Hyperinsulinism (excessive insulin production)
• Renal insufficiency (reduced kidney function)
• Obesity
• Insulinoma (a rare pancreatic tumor that produces insulin)
• Cushing’s syndrome (excessive production of the hormone cortisol)

How is the analysis performed?

The analysis of C-peptide in urine is carried out by taking a urine sample that is then sent to the laboratory for further analysis. The test is simple, non-invasive, and does not require special preparation.

Preparation for C-peptide analysis in urine

This test does not require special preparation. However, it is important to inform your doctor about any medications you are currently using before the analysis, as some medications can affect the results of the test.