APCR (Activated Protein C Resistance)

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2500,00 rsd

Obrtno Vreme

4h

Uzorkovanje

Blood Draw

Kategorija

Hemostasis

Activated Protein C Resistance (APCR) is a complex phenomenon involving the body’s reduced sensitivity to the inhibition of coagulation by activated protein C. This specific test, available at IntroLab, plays a crucial role in identifying genetic and laboratory risk factors for thrombosis. Understanding the specifics and types of this test can help you better manage your health and potential risks.

What is APCR (Activated Protein C Resistance)?

APCR is a genetic and laboratory disorder affecting blood coagulation. It is characterized by the body’s reduced sensitivity to the inhibition of coagulation by activated protein C (APC). APC is a natural anticoagulant that regulates the blood clotting process.

APCR is commonly caused by the hereditary factor V Leiden mutation, the most frequent cause of inherited thrombophilia. This mutation alters factor V, preventing APC from properly inactivating it, leading to an increased risk of thrombosis.

When is this test performed?

The APCR test is usually conducted using a coagulation test. It compares clotting time with and without the addition of APC to determine the body’s sensitivity to APC. APCR testing is important for several reasons:

  • History of Thrombosis: Individuals with a history of thrombosis, especially younger people or those without other obvious risk factors, may be candidates for APCR testing.
  • Factor V Leiden Mutation: If there is suspicion of a factor V Leiden mutation, APCR testing can help confirm the diagnosis. Factor V Leiden is the most common genetic factor for thrombophilia and is associated with an increased risk of venous thrombosis.
  • Family History of Thrombosis: Individuals with a family history of thrombosis, particularly if close relatives have experienced it, may be tested for APCR to identify hereditary risk factors.
  • Recurring Miscarriages: APCR may be tested in women who have had recurring miscarriages, as resistance to activated protein C can be associated with vascular circulation problems in the placenta.

Preparation for the Test

Individuals who have not had thrombosis do not require special preparation for the Activated Protein C Resistance (APCR) test. However, it is recommended not to take the test immediately after a meal to ensure accurate results. Those who have previously experienced thrombosis should consult their doctor before undergoing APCR testing. In these cases, it is often necessary to pause anticoagulant therapy for a period before the test to ensure reliable results.

Vrsta uzorka i vreme kada se uzima uzorak

Uzorak: Citrated Plasma (Venous Blood)

Obrtno vreme: 4h

Priprema: Consult your doctor before the test.

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