Antithrombin III

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2300,00 rsd

Obrtno Vreme

4h

Uzorkovanje

Blood Draw

Kategorija

Hemostasis

The Antithrombin III test, which measures the level of antithrombin III—a protein crucial for regulating the blood clotting process—can be performed at IntroLab in Belgrade.

What is Antithrombin III?

Antithrombin III is a protein in the blood that plays a vital role in regulating the clotting process. It is a natural anticoagulant that inhibits thrombin and other proteases in the coagulation system. Thrombin is an enzyme that directly leads to blood clot formation, so by inhibiting it, antithrombin III helps prevent uncontrolled or excessive clotting.

A deficiency in this protein can lead to a condition known as antithrombin deficiency. This disorder increases the risk of developing abnormal blood clots and can be either hereditary (primary) or acquired (secondary) due to other medical conditions or treatments.

Why is this test performed?

This test is useful for diagnosing conditions that affect blood coagulation. For example, low levels of antithrombin III may indicate antithrombin III deficiency. This condition can increase the risk of forming abnormal blood clots, which can lead to deep vein thrombosis (DVT) or pulmonary embolism (PE).

The test is also beneficial for monitoring the effectiveness of anticoagulant therapy. Individuals at high risk of blood clots, including those with hereditary coagulation disorders, may be on long-term anticoagulant therapy. Monitoring antithrombin III levels helps doctors evaluate whether this therapy is effective.

Specifics and Types of Antithrombin III Tests

The analysis of antithrombin III involves two main methods: testing for activity and detecting the antigen.

  • Activity Test: This measures the functional activity of antithrombin III in the blood. It evaluates how effectively the protein inhibits thrombin and other proteases in the coagulation system. Reduced activity can indicate a deficiency.
  • Antigen Test: This measures the total amount of antithrombin III in the blood, regardless of its functionality. It helps distinguish between hereditary and acquired forms of deficiency.

In some cases, both tests may be performed together to provide a more comprehensive understanding of the patient’s status. The decision on which tests to use and how to interpret the results depends on the clinical situation and should be made in consultation with a qualified healthcare professional.

Preparation for the Test

Patients who have had thrombosis, especially those on anticoagulant therapy, must carefully follow their doctor’s instructions. Current anticoagulant therapy and recent thromboembolic events can affect the results of the test. Medications like heparin and warfarin can temporarily lower antithrombin III levels in the blood. Therefore, it is often necessary to wait a certain period after the last dose of anticoagulants or after a thrombotic event before reliably performing the test.

Individuals who have not experienced thrombosis do not have specific preparation requirements for this test. However, it is ideal that the blood sample not be taken immediately after a meal.

Vrsta uzorka i vreme kada se uzima uzorak

Uzorak: Citrate plasma (venous blood)

Obrtno vreme: 4h

Priprema: No special preparation is needed for the test. However, it is recommended to avoid taking the sample immediately after a meal.

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