ACE (Angiotensin-Converting Enzyme)

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1500,00 rsd

Obrtno Vreme

1 day

Uzorkovanje

Blood Draw

Kategorija

Immunohemistry

The ACE (Angiotensin-Converting Enzyme) test is a critical diagnostic tool that provides essential information about heart and blood vessel health. Recognizing its importance, IntroLab is dedicated to delivering high-quality and reliable analyses for its patients.

What is Angiotensin-Converting Enzyme (ACE)?

Angiotensin-Converting Enzyme (ACE) is an enzyme that plays a crucial role in regulating blood pressure and maintaining cardiovascular system function. It is found in various tissues and organs, including the lungs, kidneys, heart, and blood vessels.

Function of the ACE Enzyme in the body

The ACE enzyme plays a key role in regulating vascular tone and maintaining fluid balance in the body. It converts the inactive hormone angiotensin I into the active hormone angiotensin II. Angiotensin II causes blood vessels to narrow (vasoconstriction) and increases blood pressure. Additionally, the ACE enzyme breaks down bradykinin, a substance that promotes vasodilation.

Relationship between the ACE Enzyme, blood pressure, and the vascular system

An imbalance in ACE enzyme activity can disrupt blood pressure regulation and blood vessel function. High levels of the ACE enzyme can lead to increased blood pressure and a higher risk of developing hypertension. Conversely, low levels of the ACE enzyme can be associated with a reduced ability to maintain normal blood pressure.

When is ACE (Angiotensin-Converting Enzyme) testing performed?

ACE testing is recommended in the following situations:

  • Diagnosis of Hypertension: ACE testing can help assess the risk of hypertension and determine the presence of high blood pressure.
  • Monitoring Cardiovascular Diseases: Individuals diagnosed with heart conditions such as heart failure, coronary artery disease, or arrhythmias may undergo ACE testing to monitor the function of the heart and blood vessels.
  • Heart Failure: ACE testing can help evaluate the severity and progression of heart failure, which is characterized by the heart’s reduced ability to pump sufficient blood.
  • Systemic Vasculitis: ACE testing can be useful in diagnosing and monitoring certain autoimmune diseases that affect the blood vessels, such as systemic lupus erythematosus, Wegener’s granulomatosis, or Churg-Strauss syndrome

Conditions and diseases diagnosed with ACE Enzyme test

The ACE test can provide information about the following conditions and diseases:

  • Sarcoidosis: Elevated ACE levels can indicate sarcoidosis, a chronic disease affecting various organs, including the lungs, skin, eyes, and heart.
  • Lung Diseases: The ACE test can assist in diagnosing lung conditions such as pulmonary fibrosis or interstitial lung diseases.
  • Kidney Diseases: High ACE levels can be associated with certain kidney disorders, such as nephrotic syndrome or lupus nephritis.
  • Neurological Diseases: In rare cases, the ACE test can be part of diagnosing certain neurological conditions, such as neurosarcoidosis.

Specifics and subtypes of the ACE Test

The ACE test includes various methods and subtypes that provide additional information about the activity of the ACE enzyme and its role in the body.

  • Methods of ACE Enzyme Testing: There are different methods for testing the ACE enzyme, including spectrophotometry, immunoassay techniques, and enzyme-linked immunosorbent assay (ELISA). Each method has its own characteristics and advantages, but all aim to measure the level of the ACE enzyme in a blood sample.
  • Specific Subtypes of Testing: In addition to the standard ACE test that measures the total level of the ACE enzyme, there are specific subtypes of testing that can provide more detailed information. For example, ACE genotyping identifies genetic variations in the ACE enzyme gene that can affect its activity. This subtype of testing can be useful in determining genetic risk for certain diseases and in individualizing therapy.

Interpretation of ACE test results and their significance

Interpreting the results of the ACE test is essential for understanding the enzyme’s activity and its implications for the patient’s health. The results are expressed in units of activity (U/L) or compared to reference values.

High levels of ACE enzyme

Elevated ACE enzyme levels can indicate various conditions and diseases, such as sarcoidosis, lung diseases, kidney diseases, or other inflammatory processes in the body. In such cases, further diagnostic procedures may be necessary to confirm the diagnosis and identify the cause of increased ACE enzyme activity.

Low Levels of ACE enzyme

Reduced ACE enzyme levels may be associated with decreased cardiovascular system functionality or a response to therapy. Low ACE enzyme levels can also indicate certain conditions, such as systemic autoimmune diseases or neurological disorders.

Vrsta uzorka i vreme kada se uzima uzorak

Uzorak: Serum (Venous Blood)

Obrtno vreme: 1 day

Priprema: If you are taking ACE inhibitors, follow your doctor's instructions before the ACE test. You may need to temporarily discontinue your medication.

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